Radiopharmaceutical Services
- At A Glance
- Key Markets
- Value Proposition
- Partners
- Services Offered
- GMP Facilities
- Applied R&D Services
- Contact
At A Glance
Overview
Over 500 employees and several partners supply over 500 customers with around 30 products across 60 countries.
- Founded in 1946
- Publicly traded: TSX: NDN NYSE: NDZ
- 2011 Revenue: 274 million USD
Key Markets
Nordion is a global health science company that provides market-leading products used for the prevention, diagnosis and treatment of disease. We are a leading provider of medical isotopes, targeted therapies and sterilization technologies that benefit the lives of millions of people in more than 60 countries around the world.
Medical Isotopes
Nordion is a world leader in medical isotope processing, packaging and delivery.
Key Priorities:
- Secure long-term medical isotope supply
- Expand marketing, research and
development capabilities
Market Leadership Position:
- Medical isotopes (Mo-99)
Primary Segments:
- Cardiology
- Oncology
- Neurology
Targeted Therapies
Nordion supplies targeted therapies for a variety of cancers as well as services for radiopharmaceutical development, and clinical and commercial manufacturing.
Key Priorities:
- Grow TheraSphere global market position
- Expand radiopharmaceutical product development
- Drive organic growth through innovation and partnerships
Market Leadership Positions:
- Radioembolization (localized internal radiation) for the treatment of liver cancer
- Radiopharmaceutical development and contract manufacturing
Primary Segments:
- Interventional oncology
Sterilization Technologies
Our innovative and industry-leading technologies are used to sterilize medical devices, instruments and supplies for the prevention of disease. Almost half of the world’s single-use medical supplies and devices are sterilized with this technology.
Key Priorities:
- Optimize value of cobalt
- Expand existing product offerings into new global markets
- Build on strong market position
Market Leadership Position
- Gamma sterilization technology
Primary Segments:
- Medical Surgical Supplies
- Medical Devices
- Consumer Products
Value Proposition
Quality
- cGMP/GLP facilities
- Leading global developer and supplier of radiotherapeutics for the treatment of non-Hodgkin’s Lymphoma
- Extensive infrastructure that is unmatched in the industry and difficult to duplicate
- World class quality assurance and quality control staff and processes
Reliability
- Nordion has demonstrated the capability to supply more than half of the world’s medical isotopes for medical imaging
- Six decades of collective knowledge and expertise in a diverse array of technologies and disciplines, including radiochemistry and radiolabeling of compounds
- Redundant safety control systems and environmental protection systems
Compliance
- ISO 14001:2004 Certified
- ISO 9001 Certified
- Extensive regulatory experience with regulators for radioactive materials (CNSC, USNRC, and IAEA)
- Extensive regulatory experience with drug regulators (FDA, EMEA, Health Canada)
Integration
- R&D partnerships for faster and more effective drug development
- Fully Integrated from isotopes to radiopharmaceuticals
- Unparalleled logistics capabilities to get product to destination on time every time
Partners
A Selection of Nordion Partners
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Radiopharmaceutical Services Offered
Nordion provides a breadth of radiopharmaceutical services and expertise.
These include:
- Radioisotope production, processing, purification
- Sterile radioisotope supply
- Radiolabeling process development
- Validation (facility, equipment, process, cleaning)
- QA/QC
- Regulatory Affairs
- Formulation development
- Scale-up (clinical and commercial supply)
- Sterile fill/finish
- Packaging development/labeling
- Distribution/logistics
- cGMP manufacturing for clinical or commercial supply
GMP Facilities
Our headquarters in Ottawa, Canada feature over 80,000 square feet of state-of-the-art manufacturing facilities to meet customer demand for medical isotopes, radiopharmaceuticals and contract manufacturing.
Our Vancouver operation uses 2 dedicated cyclotrons for SPECT isotope production and are world leaders in radiolabeling, especially with Iodine-123.
Radiopharmaceutical Production
Using our highly trained and specialized team, we prepare
radioisotopes for customers around the world.
Nordion maintains a host of radiopharmaceutical hot cell suites for contract manufacturing and production.
Quality Control
Our expert team of quality professionals with state-of-the-art equipment assures products meet or exceed specifications.
Nuclear and pharmaceutical ventilation system
Nordion has developed innovative ways of addressing the conflicting demands of nuclear ventilation (protect the people) and pharmaceutical ventilation (protect the product).
Warehouse/Inventory
We maintain an enhanced fleet of radioisotope shipping containers in an environmentally and access controlled warehouse.
Waste Handling
Nordion provides comprehensive waste management solutions for radioisotopes and radiopharmaceuticals.
Central Monitoring
All key facility parameters are monitored 24/7 to assure ongoing compliance.
Packaging
Radiopharmaceutical unit doses can be packaged in a variety of configurations and shipped under strict environmental controls.
Logistics
Our dedicated fleet takes product to commercial carriers for distribution to customers worldwide, usually the next day.
Applied R&D Services
As a global leader and proven partner in isotopes and radiopharmaceutical services, Nordion has established a reliable quality offering in applied R&D services to leading biotechnology and pharmaceutical companies.
Medical imaging can be applied at all stages of drug discovery and development—from validating disease-relevant targets to pre-clinical evaluation and selection of drug candidates—through to clinical development and pharmacovigilance.
Dedicated Labs
Molecular Imaging Centre located at the University of Ottawa Heart Institute offers labs that are:
- State-of-the-art
- In a confidential environment
- GLP certified
- With access to micro and clinical cameras
Dedicated Team
We have a skilled multidisciplinary and dedicated team, including:
- Biologists
- Chemists
- Physicists
- Imaging physicists
- Bio-infomatists
- Clinicians
Studies/Services
Our wide offering is tailored to customers’ needs and features studies ranging from, but not limited to:
- Target identification/targeting
- Receptor binding/occupancy
- Pharmacokinetics/Pharmacodynamics
- Drug delivery
- Validation
- Translational imaging possibilities
Specialized Knowledge
Nordion’s specialized knowledge in radiopharmaceutical development and manufacturing helps biotechnology and pharmaceutical companies bring new drugs from concept to market reality. We can help at each step of the drug discovery and development process.
Our capabilities and services include:
- Radioisotope supply – both reactor and cyclotron based
- Radiochemistry development – proprietary chelates, conjugation, iodination
- Radiolabeling expertise, including:
- Preliminary radiolabeling using multiple radioisotopes to generate and screen leads for potential products
- Post labeling characteristics and analysis
- Biodistribution studies
- Post labeling characteristics and analysis
- Radiolabeling lead candidates and detailed assessment:
- In vitro potency in tumor cell line
- In vitro efficacy studies in tumor models
- Bioanalytical assay development and validation
- Preclinical proof-of-efficacy, tumor localization, dosimetry studies
- In vitro potency in tumor cell line
- Preliminary radiolabeling using multiple radioisotopes to generate and screen leads for potential products
- Product formulation development/optimization
Contact
radiopharmservices@nordion.com
Nordion
447 March Rd.
Ottawa, ON, Canada
K2K 1X8
Phone: +1 613 592 2790
Fax: +1 613 592 6937
